Dntp triphosphohydrolase
WebApr 21, 2014 · dNTP triphosphohydrolase enzymes, such as SAMHD1, are conserved from bacteria to humans and carry out the unusual conversion of dNTPs to the … Web暨南大学,数字图书馆. 开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
Dntp triphosphohydrolase
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WebThe reaction composition was: 1 [micro]l of DNA sample (from stock, or dilutions 1:10, 1:100, 1:200 or 1:400; diluted DNA samples were used to overcome inhibition effects of … WebDec 6, 2016 · In mammalian cells, an additional factor regulating dNTP levels is SAMHD1 (SAM And HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase 1), a dNTP hydrolase that maintains low levels of dNTPs outside of S phase, but which is proteolysed in S phase (, reviewed in ). Maintaining dNTP concentrations at levels …
WebApr 8, 2024 · Mechanistically, it has been shown that Vpx is able to recognize and bind the dNTP triphosphohydrolase (dNTPase) SAMHD1 and trigger its degradation via the CUL4A·DDB1·DCAF ubiquitin ligase complex [8]. SAMHD1 naturally regulates the intracellular dNTP pool, yet it also restricts infections of retroviruses and several DNA … WebJan 22, 2024 · The crystal structure of the dNTP triphosphohydrolase PA1124 was determined. • PA1124 assembles into a hexameric architecture as a trimer of dimers. • PA1124 binds ssDNA via an intersubunit cleft presumably as an allosteric regulator. • PA1124 interacts with a metal ion using conserved histidine and aspartate residues. •
WebMay 25, 2006 · Deoxyribonucleoside triphosphate triphosphohydrolase from Thermus thermophilus (Tt-dNTPase) has a unique regulatory mechanism for the degradation of … WebAug 22, 2024 · SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection and is dysregulated in Aicardi-Goutières syndrome and cancer. Daddacha et al. define a dNTPase-independent function for SAMHD1 in HR-mediated DSB repair by facilitating CtIP accrual to promote DNA end resection, providing insight into how SAMHD1 promotes …
WebNov 8, 2007 · Deoxyribonucleoside triphosphate (dNTP) triphosphohydrolase (dNTPase) from Thermus thermophilus HB8 (TTHB8) belongs to HD superfamily proteins and …
WebOf the four deoxyribonucleoside triphosphate (dNTP) pools in S phase mouse embryo cells, the dCTP pool is the largest and the dGTP pool by far the smallest (Skoog and … csh if pattern matchWebJan 23, 2007 · PTHR11373:SF32 DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE 1 hit; PROSITE. View protein in PROSITE; PS51831 HD 1 hit; Pfam. View protein in Pfam; PF01966 HD 1 hit; PF13286 HD_assoc 1 hit; SMART. View protein in SMART; SM00471 HDc 1 hit; TIGRFAMs. TIGR01353 dGTP_triPase 1 hit; … csh if regular expressionWebJun 8, 2024 · The expression of SAMHD1, a dNTP triphosphohydrolase, restricts viral infection, particularly in non-dividing cells, by depleting cellular dNTPs which are essential for viral reverse transcription as well as … csh ifsWebJun 23, 2024 · This is a result of SAMHD1-dNTP triphosphohydrolase activity that blocks early stage infection through depletion of the dNTP pool to a level that cannot support viral reverse transcription 13 – 16. In addition, SAMHD1 also inhibits replication of the DNA viruses, herpes simplex virus type 1 and vaccinia virus in monocyte-derived … eag full formWebHowever, inhibitors that target these genes will face a challenge like most therapeutic molecules—access to a tumor. Recently, it has been demonstrated that a SAMHD1 promotes DNA damage repair [84, 85], involved in processing DNA at collapsed replication fork [86, 87], independent of its well-established dNTP triphosphohydrolase activity [58 ... eagg dealer pawn feverWebDeoxyribonucleoside triphosphate triphosphohydrolase from Thermus thermophilus (Tt-dNTPase) has a unique regulatory mechanism for the degradation of deoxyribonucleoside triphosphates (dNTPs).Structural comparison with other HD-superfamily proteins indicates that a pocket at the centre of the inner six helices, formed from highly conserved charged … eag for a1cWebSep 4, 2024 · Elevated intracellular levels of dNTPs have been shown to be a biochemical marker of cancer cells. Recently, a series of mutations in the multifunctional dNTP triphosphohydrolase (dNTPase), sterile alpha motif and histidine–aspartate domain–containing protein 1 (SAMHD1), have been reported in various cancers. Here, … eagfwe