Cisplatin h460

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WebJan 26, 2012 · The cisplatin resistant clone (H460/cis) of H460 cells was established by exposing the cells with gradually increasing concentrations of cisplatin until chemoresistance acquisition was elucidated by MTT, Hoechst 33342 staining and comet assays. Degree of autophagosome formation and level of LC3 marker were evaluated by … Web目的基于基因芯片数据分析非小细胞肺癌H460细胞株顺铂耐药相关的靶基因及信号传导通路.方法从基因表达数据库 (GEO)下载基因芯片数据,数据预处理后,使用R软件分析H460顺铂耐药细胞株与亲本细胞株中差异表达的基因.运用生物医学信息学方法 (基因本体论使用 ...

鸦胆子素A诱导非小细胞肺癌细胞株H460凋亡及机制的初步研究

WebNov 5, 2024 · Oroxylin A attenuates hypoxia-induced cisplatin resistance a H460 cells were treated with cisplatin under normoxic (20% O2) or hypoxic (1% O2) condition for 36 h. The cell viability was analyzed ... WebApr 14, 2024 · To verify the resistance of A549/CR and H460/CR cells, the effect of cisplatin or PGG on viability (Figure 1A) and the PTEN expression level was examined in A549 and H460 parental cells and cisplatin-resistant A549/CR and H460/CR cells using an MTT assay and Western blotting. Cisplatin-resistant cell lines demonstrated a subtle … how many kilometers in 1 foot

Oroxylin A reverses hypoxia-induced cisplatin resistance through ...

WebOct 31, 2024 · Generation of Cisplatin-Resistant Lung Cancer Cell Lines A549, H460, H661, and H1299 lung cancer cells were exposed to cisplatin according to the IC50 value for 72 h. The medium was removed, and the cells were cultured in normal medium until the cells fully recovered. WebMay 1, 2024 · Cisplatin-resistant versions of the A549, H1299, and H460 cell lines were generated by continuous drug exposure. The long-term metabolic changes, as well as, the early response to cisplatin treatment were analyzed in both, parental and cisplatin-resistant cell lines. WebJan 26, 2024 · Emodin enhances cisplatin-induced DNA damage in A549 and H460 cells Cisplatin mainly kills tumor cells by inducing DNA damage ( 30 ). The effect of emodin on the chemosensitivity of A549 and H460 … howard s phillips florida

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Cisplatin Intravenous: Uses, Side Effects, Interactions

WebCISPLATIN 10 MG INJECTION: Short descriptive text of procedure or modifier code (28 characters or less). The AMA owns the copyright on the CPT codes and descriptions; … WebApr 13, 2024 · Cisplatin‑resistant A549 (A549/CDDP) and H460 (H460/CDDP) cells were first established and were then transfected with negative control small interfering (si)RNA (si‑NC) or TRPC1 siRNA (si‑TRPC1). Cells were then treated with 740 Y‑P, a PI3K/Akt agonist. Subsequently, the sensitivity of A549/CDDP and H460/CDDP cells to CDDP … howard spicer obituary howard spike west hills ca

"WebSep 1, 2006 · Figure 2C shows that H460-pMEP 4-MKP-1 cells treated with CdSO 4 were more resistant to both doses of cisplatin compared with the control H460-pMEP 4 vector cells . Thus, these results indicate that overexpression of MKP-1 plays a critical role in cisplatin resistance in the H460 human lung cancer cell. " - Cisplatin h460

Cisplatin h460

Injection, cisplatin, powder or solution, 10 mg - HIPAASpace

WebC is-diamminedichloroplatinum(II) (cisplatin) is the most celebrated metal-based chemotherapeutic in the history of modern medicine.The discovery of its anticancer effects was not only opportune [1,2,3], especially during a period when cancer prevention was desperately needed, but also because medical oncology did not yet exist as a clinical … WebJan 17, 2013 · Cisplatin concentrations (IC 50) varied between all four cell lines (A549 5.95 µM, SKMES-1 2.65 µM, MOR 3.3 µM, H460 5.0 µM) and were subsequently used to treat each parent cell line in order to generate corresponding age and passage-matched cisplatin resistant cell lines. In the case of H460 cells, maintenance of the resistant subline was ...

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Web2 days ago · LUAD cell lines H1299, H460, A549, H1975, CALU1 and CALU6, lung fibroblasts HEL299, lung bronchial epithelial cell line HBEC, normal human bronchial epithelium cell line BEAS2B, kidney embryonic ... WebOct 1, 2024 · Similar in CRPC, para-toluenesulfonamide inhibited the Akt/mTOR/p70S6K pathway in NSCLC cell lines NCI-H460 and A549, leading to G1 arrest of the cell cycle and apoptosis. Para-toluenesulfonamide significantly decreased the cholesterol levels of plasma membrane. ... (Figure 7A,B) but not that with paclitaxel or cisplatin (Figure S6 ...

WebJul 13, 2024 · a H460 cells were reprogrammed using the Stemgent mRNA Reprogramming System (Reprocell, Beltsville, MD, USA). Schedule for establishing R-H460 cells by transfecting the mRNAs of reprogramming... WebLung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional Chinese medicine (TCM) as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in …

WebApr 9, 2024 · In vitro cytotoxicity of free cisplatin and G4.0-PAA/aquated cisplatin nano-complex against NCI H460 cells (human lung cancer cells) was evaluated by SRB assay, and their corresponding IC 50 values were calculated from the dose–response curves using non-linear regression analysis. The cells were incubated for 5 h at pH 7.4 in the … WebJul 28, 2024 · Results: Herein, role of autophagy in cisplatin resistance was indicated by a decreased cell viability and increased apoptosis in lung cancer H460 cells pre-incubated …

WebInjection, cisplatin, powder or solution, 10 mg: BETOS Code: O1D - Chemotherapy: Action Code: N - No maintenance for this code: Type of Service Code: 1 - Medical care: Pricing …

WebFeb 4, 2024 · H460 cells showed a greater sensitivity to cisplatin with 41% inhibition of colony formation at 1 µM cisplatin and 80% inhibition at 2 µM, compared with 23% and 32%, respectively, for A549... how many kilometers in 3000 milesWebCisplatin induces A549 and H460 cell apoptosis via the mitochondrial‑associated pathway (A and B) After treatment with 10, 20 and 40 µM cisplatin, cell apoptosis was detected using flow... howard spicerWebFlap endonuclease 1 (FEN1) plays a crucial role in both DNA replication and damage repair. In this study, we investigated FEN1 expression and its clinical-pathological significance in non-small-cell lung cancer (NSCLC). Quantitative reverse PCR and howard spiegelman compassWebDec 16, 2015 · H460 lung cancer cells increased cisplatin sensitivity and showed reduced repair of both . intrastrand and interstrand adducts suggesting that the mechanism of sensitivity is primarily . howard spizer attorney paWebApr 10, 2024 · Microarray data from resistant and sensitive cisplatin H460 lung cancer cell line: Data processing: The analysis and visualization of the microarray data was performed using Agilent Cytogenomic 3.0.1.1. Submission date: Apr 11, 2024: Last update date: Apr 10, 2024: Contact name: Carlos Rodriguez Antolin: Organization name howards peugeot yeovilWebConversely, H460 cisplatin-resistant cells showed increased tendency to develop bone metastasis. Gene expression analysis showed that several genes involved in tumor … how many kilometers in 400 milesWebResistance mechanism to cisplatin in NCI-H460 non-small cell lung cancer cell line: investigating apoptosis, autophagy, and cytogenetic damage … howard s pittle